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This section contains a summary of some of the key trials published in peer-reviewed medical journals, and begins with a summary of the International EECP Patient Registry of over 5000 patients, which provides data demonstrating therapeutic outcomes and duration of benefit, and the CCS functional class system.


The Canadian Cardiovascular Society Functional Classification of Angina


The table below outlines a scoring system to grade the severity of symptoms suffered by people with angina. If you have angina you may wish to look at the table below to grade your symptoms of angina against the classes I (mild) to IV (severe).



Data gathered by International EECP Patient Registry of over 5,000 patients (see IEPR study below) showed:



EECP Clinical ratings table


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The International EECP Patient Registry (IEPR) provides data demonstrating therapeutic outcomes and duration of benefit

Summary of The International EECP Patient Registry (IEPR)


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MUST-EECP




Congestive Heart Failure Feasibility Study  



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THE PEECH TRIAL


The Prospective Evaluation of EECP in Congestive Heart Failure (PEECH) trial evaluated the efficacy of EECP therapy for the treatment of congestive heart failure.  The results demonstrated that EECP therapy was significantly more effective in improving exercise duration than optimal pharmacologic therapy alone.  


After six months, exercise time increased in the EECP group and decreased in the control group.  Additional endpoints of

symptom status, assessed by New York Heart Association (NYHA) functional class, improved 31% in the EECP group compared to 16% in the control group.  Overall quality of life also improved significantly among patients treated with EECP therapy.  


CENTRAL HAEMODYNAMICS


In this cath lab study Michaels, et al demonstrated that: "EECP unequivocally and significantly increases diastolic and mean pressures and reduces systolic pressure in the central aorta and coronary artery. Coronary artery flow, determined by both Doppler and angiographic techniques, is increased during EECP. The combined effects of systolic unloading and increased coronary perfusion pressure provide evidence that EECP may serve as a potential mechanical assist device."


Michaels, et al, 4 University of California, San Francisco, CA


Summary table:  Published Controlled and Uncontrolled Trials of EECP in Patients with Stable Angina

Summary table of EECP Trials


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EECP lowers systolic blood pressure

 

A recent study looking at 108 patients undergoing EECP showed systolic blood pressure reduces significantly following EECP treatment.

 

Stratified differences were sustained after individual EECP sessions, at the end of the course of EECP, and 6 weeks after the final EECP session and were independent of changes in cardiovascular medications. The reduction in systolic blood pressure is likely to contribute to the beneficial outcomes seen with EECP.

 

Am Heart J. 2008 Dec;156(6):1217-22.


Clinical Data - Key Trials